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Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila.

ABSTRACT: In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese herbal medicine for insomnia. Short-term insomnia and hypnotic use both attenuate cognitive functions, especially learning memory. In previous studies, A. julibrissin exhibits sedative activity, antidepressant-like effects, and protection of learning and memory against amnesia. However, whether A. julibrissin ameliorates memory loss caused by short-term sleep deprivation is not clear. We utilized the sleep-deprived Drosophila model and olfactory associative learning-memory assay to test the effects of A. julibrissin on sleep-deprivation induced memory loss. We found that A. julibrissin ameliorated 3-hour memory but not 1-hour memory or instant learning. The findings might be applied to an anticipated short-term sleep disturbance.

SUBMITTER: Chang JS

PROVIDER: S-EPMC6463593 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Albizia julibrissin Ameliorates Memory Loss Induced by Insomnia in Drosophila.

Chang Jui-Shu JS Liu Hsin-Ping HP Cheng Jack J Chen Chao-Jung CJ Hwang Su-Lun SL Tseng Chi-Chuan CC Hsu Lee-Fen LF Lin Wei-Yong WY

Evidence-based complementary and alternative medicine : eCAM 20190401

In clinical practice in Taiwan, Albizia julibrissin is the most prescribed Chinese herbal medicine for insomnia. Short-term insomnia and hypnotic use both attenuate cognitive functions, especially learning memory. In previous studies, A. julibrissin exhibits sedative activity, antidepressant-like effects, and protection of learning and memory against amnesia. However, whether A. julibrissin ameliorates memory loss caused by short-term sleep deprivation is not clear. We utili ...[more]

PMID: 31057652

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