Ontology highlight
ABSTRACT:
SUBMITTER: Finn J
PROVIDER: S-EPMC6464111 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Cell reports 20190301 11
Lung alveolar type I cells (AT1) and alveolar type II cells (AT2) regulate the structural integrity and function of alveoli. AT1, covering ∼95% of the surface area, are responsible for gas exchange, whereas AT2 serve multiple functions, including alveolar repair through proliferation and differentiation into AT1. However, the signaling mechanisms for alveolar repair remain unclear. Here, we demonstrate, in Pseudomonas aeruginosa-induced acute lung injury in mice, that non-canonical Notch ligand ...[more]