Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC4566105 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Liu Yuru Y Kumar Varsha Suresh VS Zhang Wei W Rehman Jalees J Malik Asrar B AB
American journal of respiratory cell and molecular biology 20150701 1
The alveolar epithelium is composed of two cell types: type I cells comprise 95% of the gas exchange surface area, whereas type II cells secrete surfactant, while retaining the ability to convert into type I cells to induce alveolar repair. Using lineage-tracing analyses in the mouse model of Pseudomonas aeruginosa-induced lung injury, we identified a population of stem cell antigen (Sca)-1-expressing type II cells with progenitor cell properties that mediate alveolar repair. These cells were sh ...[more]