Ontology highlight
ABSTRACT:
SUBMITTER: Chatterjee S
PROVIDER: S-EPMC6465090 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chatterjee Sudeshna S Ade Carina C Nurik Caitlin E CE Carrejo Nicole C NC Dutta Chayan C Jayaraman Vasanthi V Landes Christy F CF
The journal of physical chemistry. B 20181227 1
The intracellular C-terminal domain (CTD) of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor undergoes phosphorylation at specific locations during long-term potentiation. This modification enhances conductance through the AMPA receptor ion channel and thus potentially plays a crucial role in modulating receptor trafficking and signaling. However, because the CTD structure is largely unresolved, it is difficult to establish if phosphorylation induces conformational changes t ...[more]