Ontology highlight
ABSTRACT:
SUBMITTER: Su TA
PROVIDER: S-EPMC6465169 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Su Timothy A TA Shihadih Diyala S DS Cao Wendy W Detomasi Tyler C TC Heffern Marie C MC Jia Shang S Stahl Andreas A Chang Christopher J CJ
Journal of the American Chemical Society 20181015 42
Copper deficiency is implicated in a variety of genetic, neurological, cardiovascular, and metabolic diseases. Current approaches for addressing copper deficiency rely on generic copper supplementation, which can potentially lead to detrimental off-target metal accumulation in unwanted tissues and subsequently trigger oxidative stress and damage cascades. Here we present a new modular platform for delivering metal ions in a tissue-specific manner and demonstrate liver-targeted copper supplementa ...[more]