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Therapeutic targeting of gastrointestinal cancer stem cells.

ABSTRACT: Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.

SUBMITTER: Stem J 

PROVIDER: S-EPMC6886570 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Therapeutic targeting of gastrointestinal cancer stem cells.

Stem Jonathan J   Flickinger John C JC   Merlino Dante D   Caparosa Ellen M EM   Snook Adam E AE   Waldman Scott A SA  

Regenerative medicine 20190426 4

Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current litera  ...[more]

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