Ontology highlight
ABSTRACT:
SUBMITTER: Nation RL
PROVIDER: S-EPMC6466603 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nation Roger L RL Rigatto Maria Helena P MHP Falci Diego R DR Zavascki Alexandre P AP
Antibiotics (Basel, Switzerland) 20190314 1
Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-negative bacteria; however, nephrotoxicity associated with these drugs is a very common side effect that occurs during treatment. This article briefly reviews nephrotoxic mechanisms and risk factors for polymyxin-associated acute kidney injury (AKI) and discusses dosing strategies that may mitigate kidney damage without compromising antimicrobial activity. Polymyxins have a very narrow therapeutic window and pa ...[more]