Ontology highlight
ABSTRACT:
SUBMITTER: McKay EC
PROVIDER: S-EPMC6467199 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
McKay Erin C EC Beck John S JS Khoo Sok Kean SK Dykema Karl J KJ Cottingham Sandra L SL Winn Mary E ME Paulson Henry L HL Lieberman Andrew P AP Counts Scott E SE
Journal of neuropathology and experimental neurology 20190501 5
Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant changes that could offer clues for future therapeutic direction. Microarray-based profiling and validation studies of postmortem frontal cortex samples from VaD, Alzheimer disease, ...[more]