Dataset Information

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

ABSTRACT: The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

SUBMITTER: Bentley AR

PROVIDER: S-EPMC6467258 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Bentley Amy R AR Sung Yun J YJ Brown Michael R MR Winkler Thomas W TW Kraja Aldi T AT Ntalla Ioanna I Schwander Karen K Chasman Daniel I DI Lim Elise E Deng Xuan X Guo Xiuqing X Liu Jingmin J Lu Yingchang Y Cheng Ching-Yu CY Sim Xueling X Vojinovic Dina D Huffman Jennifer E JE Musani Solomon K SK Li Changwei C Feitosa Mary F MF Richard Melissa A MA Noordam Raymond R Baker Jenna J Chen Guanjie G Aschard Hugues H Bartz Traci M TM Ding Jingzhong J Dorajoo Rajkumar R Manning Alisa K AK Rankinen Tuomo T Smith Albert V AV Tajuddin Salman M SM Zhao Wei W Graff Mariaelisa M Alver Maris M Boissel Mathilde M Chai Jin Fang JF Chen Xu X Divers Jasmin J Evangelou Evangelos E Gao Chuan C Goel Anuj A Hagemeijer Yanick Y Harris Sarah E SE Hartwig Fernando P FP He Meian M Horimoto Andrea R V R ARVR Hsu Fang-Chi FC Hung Yi-Jen YJ Jackson Anne U AU Kasturiratne Anuradhani A Komulainen Pirjo P Kühnel Brigitte B Leander Karin K Lin Keng-Hung KH Luan Jian'an J Lyytikäinen Leo-Pekka LP Matoba Nana N Nolte Ilja M IM Pietzner Maik M Prins Bram B Riaz Muhammad M Robino Antonietta A Said M Abdullah MA Schupf Nicole N Scott Robert A RA Sofer Tamar T Stancáková Alena A Takeuchi Fumihiko F Tayo Bamidele O BO van der Most Peter J PJ Varga Tibor V TV Wang Tzung-Dau TD Wang Yajuan Y Ware Erin B EB Wen Wanqing W Xiang Yong-Bing YB Yanek Lisa R LR Zhang Weihua W Zhao Jing Hua JH Adeyemo Adebowale A Afaq Saima S Amin Najaf N Amini Marzyeh M Arking Dan E DE Arzumanyan Zorayr Z Aung Tin T Ballantyne Christie C Barr R Graham RG Bielak Lawrence F LF Boerwinkle Eric E Bottinger Erwin P EP Broeckel Ulrich U Brown Morris M Cade Brian E BE Campbell Archie A Canouil Mickaël M Charumathi Sabanayagam S Chen Yii-Der Ida YI Christensen Kaare K Concas Maria Pina MP Connell John M JM de Las Fuentes Lisa L de Silva H Janaka HJ de Vries Paul S PS Doumatey Ayo A Duan Qing Q Eaton Charles B CB Eppinga Ruben N RN Faul Jessica D JD Floyd James S JS Forouhi Nita G NG Forrester Terrence T Friedlander Yechiel Y Gandin Ilaria I Gao He H Ghanbari Mohsen M Gharib Sina A SA Gigante Bruna B Giulianini Franco F Grabe Hans J HJ Gu C Charles CC Harris Tamara B TB Heikkinen Sami S Heng Chew-Kiat CK Hirata Makoto M Hixson James E JE Ikram M Arfan MA Jia Yucheng Y Joehanes Roby R Johnson Craig C Jonas Jost Bruno JB Justice Anne E AE Katsuya Tomohiro T Khor Chiea Chuen CC Kilpeläinen Tuomas O TO Koh Woon-Puay WP Kolcic Ivana I Kooperberg Charles C Krieger Jose E JE Kritchevsky Stephen B SB Kubo Michiaki M Kuusisto Johanna J Lakka Timo A TA Langefeld Carl D CD Langenberg Claudia C Launer Lenore J LJ Lehne Benjamin B Lewis Cora E CE Li Yize Y Liang Jingjing J Lin Shiow S Liu Ching-Ti CT Liu Jianjun J Liu Kiang K Loh Marie M Lohman Kurt K KK Louie Tin T Luzzi Anna A Mägi Reedik R Mahajan Anubha A Manichaikul Ani W AW McKenzie Colin A CA Meitinger Thomas T Metspalu Andres A Milaneschi Yuri Y Milani Lili L Mohlke Karen L KL Momozawa Yukihide Y Morris Andrew P AP Murray Alison D AD Nalls Mike A MA Nauck Matthias M Nelson Christopher P CP North Kari E KE O'Connell Jeffrey R JR Palmer Nicholette D ND Papanicolau George J GJ Pedersen Nancy L NL Peters Annette A Peyser Patricia A PA Polasek Ozren O Poulter Neil N Raitakari Olli T OT Reiner Alex P AP Renström Frida F Rice Treva K TK Rich Stephen S SS Robinson Jennifer G JG Rose Lynda M LM Rosendaal Frits R FR Rudan Igor I Schmidt Carsten O CO Schreiner Pamela J PJ Scott William R WR Sever Peter P Shi Yuan Y Sidney Stephen S Sims Mario M Smith Jennifer A JA Snieder Harold H Starr John M JM Strauch Konstantin K Stringham Heather M HM Tan Nicholas Y Q NYQ Tang Hua H Taylor Kent D KD Teo Yik Ying YY Tham Yih Chung YC Tiemeier Henning H Turner Stephen T ST Uitterlinden André G AG van Heemst Diana D Waldenberger Melanie M Wang Heming H Wang Lan L Wang Lihua L Wei Wen Bin WB Williams Christine A CA Wilson Gregory G Wojczynski Mary K MK Yao Jie J Young Kristin K Yu Caizheng C Yuan Jian-Min JM Zhou Jie J Zonderman Alan B AB Becker Diane M DM Boehnke Michael M Bowden Donald W DW Chambers John C JC Cooper Richard S RS de Faire Ulf U Deary Ian J IJ Elliott Paul P Esko Tõnu T Farrall Martin M Franks Paul W PW Freedman Barry I BI Froguel Philippe P Gasparini Paolo P Gieger Christian C Horta Bernardo L BL Juang Jyh-Ming Jimmy JJ Kamatani Yoichiro Y Kammerer Candace M CM Kato Norihiro N Kooner Jaspal S JS Laakso Markku M Laurie Cathy C CC Lee I-Te IT Lehtimäki Terho T Magnusson Patrik K E PKE Oldehinkel Albertine J AJ Penninx Brenda W J H BWJH Pereira Alexandre C AC Rauramaa Rainer R Redline Susan S Samani Nilesh J NJ Scott James J Shu Xiao-Ou XO van der Harst Pim P Wagenknecht Lynne E LE Wang Jun-Sing JS Wang Ya Xing YX Wareham Nicholas J NJ Watkins Hugh H Weir David R DR Wickremasinghe Ananda R AR Wu Tangchun T Zeggini Eleftheria E Zheng Wei W Bouchard Claude C Evans Michele K MK Gudnason Vilmundur V Kardia Sharon L R SLR Liu Yongmei Y Psaty Bruce M BM Ridker Paul M PM van Dam Rob M RM Mook-Kanamori Dennis O DO Fornage Myriam M Province Michael A MA Kelly Tanika N TN Fox Ervin R ER Hayward Caroline C van Duijn Cornelia M CM Tai E Shyong ES Wong Tien Yin TY Loos Ruth J F RJF Franceschini Nora N Rotter Jerome I JI Zhu Xiaofeng X Bierut Laura J LJ Gauderman W James WJ Rice Kenneth K Munroe Patricia B PB Morrison Alanna C AC Rao Dabeeru C DC Rotimi Charles N CN Cupples L Adrienne LA

Nature genetics 20190329 4

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. ...[more]

PMID: 30926973

Dataset Information

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Publications

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

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