Ontology highlight
ABSTRACT:
SUBMITTER: Friggeri L
PROVIDER: S-EPMC6467724 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20181130 23
Sterol 14α-demethylases (CYP51) are cytochrome P450 enzymes essential for sterol biosynthesis in eukaryotes and therapeutic targets for antifungal azoles. Multiple attempts to repurpose antifungals for treatment of human infections with protozoa (Trypanosomatidae) have been undertaken, yet so far none of them have revealed sufficient efficacy. VNI and its derivative VFV are two potent experimental inhibitors of Trypanosomatidae CYP51, effective in vivo against Chagas disease, visceral leishmania ...[more]