Ontology highlight
ABSTRACT:
SUBMITTER: Aneja R
PROVIDER: S-EPMC6467816 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Aneja Rachna R Grigoletto Antonella A Nangarlia Aakansha A Rashad Adel A AA Wrenn Steven S Jacobson Jeffrey M JM Pasut Gianfranco G Chaiken Irwin I
Journal of peptide science : an official publication of the European Peptide Society 20190227 4
Previously, we reported the discovery of macrocyclic peptide triazoles (cPTs) that bind to HIV-1 Env gp120, inhibit virus cell infection with nanomolar potencies, and cause irreversible virion inactivation. Given the appealing virus-killing activity of cPTs and resistance to protease cleavage observed in vitro, we here investigated in vivo pharmacokinetics of the cPT AAR029b. AAR029b was investigated both alone and encapsulated in a PEGylated liposome formulation that was designed to slowly rele ...[more]