The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.
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ABSTRACT:
SUBMITTER: Franzmeier N
PROVIDER: S-EPMC6467911 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.
Franzmeier Nicolai N Rubinski Anna A Neitzel Julia J Ewers Michael M
Nature communications 20190416 1
The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer's disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown. Here we find in 89 older individuals without dementia, that BIN1 rs744373 risk-allel ...[more]
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