Ontology highlight
ABSTRACT:
SUBMITTER: Kong P
PROVIDER: S-EPMC6468289 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Kong Peng P Yu Yuan Y Wang Lu L Dou Yong-Qing YQ Zhang Xu-Hui XH Cui Yan Y Wang Hai-Yue HY Yong Yu-Tao YT Liu Ya-Bin YB Hu Hai-Juan HJ Cui Wei W Sun Shao-Guang SG Li Bing-Hui BH Zhang Fan F Han Mei M
Nucleic acids research 20190401 7
NF-κB-mediated inflammatory phenotypic switching of vascular smooth muscle cells (VSMCs) plays a central role in atherosclerosis and neointimal formation. However, little is known about the roles of circRNAs in the regulation of NF-κB signaling. Here, we identify the involvement of circ-Sirt1 that was one of transcripts of SIRT1 host gene in VSMC inflammatory response and neointimal hyperplasia. First, in the cytoplasm, circ-Sirt1 directly interacts with and sequesters NF-κB p65 from nuclear tra ...[more]