Ontology highlight
ABSTRACT:
SUBMITTER: Hadar A
PROVIDER: S-EPMC5981646 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Hadar A A Milanesi E E Walczak M M Puzianowska-Kuźnicka M M Kuźnicki J J Squassina A A Niola P P Chillotti C C Attems J J Gozes I I Gurwitz D D
Scientific reports 20180531 1
Alzheimer's Disease (AD) is the most common cause of dementia in the elderly. Centenarians - reaching the age of >100 years while maintaining good cognitive skills - seemingly have unique biological features allowing healthy aging and protection from dementia. Here, we studied the expression of SIRT1 along with miR-132 and miR-212, two microRNAs known to regulate SIRT1, in lymphoblastoid cell lines (LCLs) from 45 healthy donors aged 21 to 105 years and 24 AD patients, and in postmortem olfactory ...[more]