Ontology highlight
ABSTRACT:
SUBMITTER: Lisa MN
PROVIDER: S-EPMC6468293 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lisa María-Natalia MN Cvirkaite-Krupovic Virginija V Richet Evelyne E André-Leroux Gwenaëlle G Alzari Pedro M PM Haouz Ahmed A Danot Olivier O
Nucleic acids research 20190401 7
Upon triggering by their inducer, signal transduction ATPases with numerous domains (STANDs), initially in monomeric resting forms, multimerize into large hubs that activate target macromolecules. This process requires conversion of the STAND conserved core (the NOD) from a closed form encasing an ADP molecule to an ATP-bound open form prone to multimerize. In the absence of inducer, autoinhibitory interactions maintain the NOD closed. In particular, in resting STAND proteins with an LRR- or WD4 ...[more]