Ontology highlight
ABSTRACT:
SUBMITTER: Hunter AW
PROVIDER: S-EPMC6468321 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
Hunter Andrew W AW Caplow Michael M Coy David L DL Hancock William O WO Diez Stefan S Wordeman Linda L Howard Jonathon J
Molecular cell 20030201 2
MCAK belongs to the Kin I subfamily of kinesin-related proteins, a unique group of motor proteins that are not motile but instead destabilize microtubules. We show that MCAK is an ATPase that catalytically depolymerizes microtubules by accelerating, 100-fold, the rate of dissociation of tubulin from microtubule ends. MCAK has one high-affinity binding site per protofilament end, which, when occupied, has both the depolymerase and ATPase activities. MCAK targets protofilament ends very rapidly (o ...[more]