Ontology highlight
ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC6469948 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Kim YoungSoo Y Yoo Yong Kyoung YK Kim Hye Yun HY Roh Jee Hoon JH Kim Jinsik J Baek Seungyeop S Lee Jinny Claire JC Kim Hye Jin HJ Chae Myung-Sic MS Jeong Dahye D Park Dongsung D Lee Sejin S Jang HoChung H Kim Kyeonghwan K Lee Jeong Hoon JH Byun Byung Hyun BH Park Su Yeon SY Ha Jeong Ho JH Lee Kyo Chul KC Cho Won Woo WW Kim Jae-Seung JS Koh Jae-Young JY Lim Sang Moo SM Hwang Kyo Seon KS
Science advances 20190417 4
Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we introduce a diagnostic technique that compares the heterogeneous and the monomerized states of Aβ in plasma. We used a small molecule, EPPS [4-(2-hydroxyethyl)-1-piperazinepropanesulfoni ...[more]