Ontology highlight
ABSTRACT:
SUBMITTER: Wang YF
PROVIDER: S-EPMC3188757 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20110510 10
Nuclear factor-κB (NF-κB) is a central regulator of immune response and a potential target for developing anti-inflammatory agents. Mechanistic studies suggest that compounds that directly inhibit NF-κB DNA binding may block inflammation and the associated tissue damage. Thus, we attempted to discover peptides that could interfere with NF-κB signaling based on a highly conserved DNA-binding domain found in all NF-κB members. One such small peptide, designated as anti-inflammatory peptide-6 (AIP6 ...[more]