Ontology highlight
ABSTRACT:
SUBMITTER: Miyamoto S
PROVIDER: S-EPMC6470178 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Miyamoto Shingo S Narita Takumi T Komiya Masami M Fujii Gen G Hamoya Takahiro T Nakanishi Ruri R Tamura Shuya S Kurokawa Yurie Y Takahashi Maiko M Mutoh Michihiro M
Scientific reports 20190417 1
In conventional research methods for cancer prevention, cell proliferation and apoptosis have been intensively targeted rather than the protection of normal or benign tumor cells from malignant transformation. In this study, we aimed to identify candidate colon cancer chemopreventive drugs based on the transcriptional activities of TCF/LEF, NF-κB and NRF2, that play important roles in the process of malignant transformation. We screened a "validated library" consisting of 1280 approved drugs to ...[more]