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Base-Promoted SNAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles.

ABSTRACT: KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed.

SUBMITTER: Iqbal MA

PROVIDER: S-EPMC6470585 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Base-Promoted SNAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles.

Iqbal Muhammad Asif MA Mehmood Hina H Lv Jiaying J Hua Ruimao R

Molecules (Basel, Switzerland) 20190322 6

KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed. ...[more]

PMID: 30909464

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