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The Neber route to substituted indoles.

ABSTRACT: Two complementary procedures have been developed for the conversion of the oximes of alpha-aryl ketones to azirines. On heating, the azirines rearrange smoothly to the corresponding indoles. The overall transformation offers a versatile route to indoles, complementary to the Fischer indole synthesis.

SUBMITTER: Taber DF 

PROVIDER: S-EPMC3258442 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature

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The Neber route to substituted indoles.

Taber Douglass F DF   Tian Weiwei W  

Journal of the American Chemical Society 20060201 4

Two complementary procedures have been developed for the conversion of the oximes of alpha-aryl ketones to azirines. On heating, the azirines rearrange smoothly to the corresponding indoles. The overall transformation offers a versatile route to indoles, complementary to the Fischer indole synthesis. ...[more]

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