Dataset Information

Flexible Carbon Nanotube-Based Polymer Electrode for Long-Term Electrocardiographic Recording.

ABSTRACT: The long-term monitoring of electrocardiogram (ECG) is critical for the accurate diagnosis and tracking of cardiovascular diseases (CVDs). However, the commercial Ag/AgCl electrode is not suitable for long-term monitoring due to skin allergies and signal degradation, caused by the conductive gel drying over time. In this paper, a flexible gel-free electrode, composed of a multi-wall carbon nanotube (MWCNT) and polydimethylsiloxane (PDMS), is proposed for long-term wearable ECG monitoring. To achieve uniform dispersion of MWCNTs in viscous PDMS, we developed a novel parallel solvent-assisted ultrasonic dispersion method, wherein the organic solvent n?Hexane served as a dispersion to avoid MWCNT aggregates. The properties of the MWCNT/PDMS electrode were assessed through structural characterization, contact impedance tests, ECG measurements, and biocompatibility tests. When the MWCNT weight fraction reached 5.5 wt%, the skin-electrode contact impedance of the MWCNT/PDMS electrode was lower than that of the Ag/AgCl electrode below 100 Hz. In daily ECG monitoring, the MWCNT/PDMS electrodes showed superior performance against motion artifact compared to the Ag/AgCl electrode. After seven days of wearing the MWCNT/PDMS electrode, ECG signals did not degrade and no side effects, such as skin redness and swelling, were observed. Thus, this electrode could enable long-term ECG monitoring in wearable healthcare systems.

SUBMITTER: Chi M

PROVIDER: S-EPMC6470748 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Flexible Carbon Nanotube-Based Polymer Electrode for Long-Term Electrocardiographic Recording.

Chi Miao M Zhao Jingjing J Dong Ying Y Wang Xiaohao X

Materials (Basel, Switzerland) 20190323 6

The long-term monitoring of electrocardiogram (ECG) is critical for the accurate diagnosis and tracking of cardiovascular diseases (CVDs). However, the commercial Ag/AgCl electrode is not suitable for long-term monitoring due to skin allergies and signal degradation, caused by the conductive gel drying over time. In this paper, a flexible gel-free electrode, composed of a multi-wall carbon nanotube (MWCNT) and polydimethylsiloxane (PDMS), is proposed for long-term wearable ECG monitoring. To ach ...[more]

PMID: 30909577

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Project description:BackgroundMulti-electrode arrays (MEAs) have become popular tools for recording spontaneous and evoked electrical activity of excitable tissues. The majority of previous studies of synaptic transmission in brain slices employed MEAs with planar electrodes that had limited ability to detect signals coming from deeper, healthier layers of the slice. To overcome this limitation, we used three-dimensional (3D) MEAs with tip-shaped electrodes to probe plasticity of field excitatory synaptic potentials (fEPSPs) in the CA1 area of hippocampal slices of 129S5/SvEvBrd and C57BL/6J-TyrC-Brd mice.ResultsUsing 3D MEAs, we were able to record larger fEPSPs compared to signals measured by planar MEAs. Several stimulation protocols were used to induce long-term potentiation (LTP) of synaptic responses in the CA1 area recorded following excitation of Schäffer collateral/commissural fibres. Either two trains of high frequency tetanic stimulation or three trains of theta-burst stimulation caused a persistent, pathway specific enhancement of fEPSPs that remained significantly elevated for at least 60 min. A third LTP induction protocol that comprised 150 pulses delivered at 5 Hz, evoked moderate LTP if excitation strength was increased to 1.5x of the baseline stimulus. In all cases, we observed a clear spatial plasticity gradient with maximum LTP levels detected in proximal apical dendrites of pyramidal neurones. No significant differences in the manifestation of LTP were observed between 129S5/SvEvBrd and C57BL/6J-TyrC-Brd mice with the three protocols used. All forms of plasticity were sensitive to inhibition of N-methyl-D-aspartate (NMDA) receptors.ConclusionPrincipal features of LTP (magnitude, pathway specificity, NMDA receptor dependence) recorded in the hippocampal slices using MEAs were very similar to those seen in conventional glass electrode experiments. Advantages of using MEAs are the ability to record from different regions of the slice and the ease of conducting several experiments on a multiplexed platform which could be useful for efficient screening of novel transgenic mice.

Dataset Information

Flexible Carbon Nanotube-Based Polymer Electrode for Long-Term Electrocardiographic Recording.

Publications

Flexible Carbon Nanotube-Based Polymer Electrode for Long-Term Electrocardiographic Recording.

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