Associations between Adipokines in Arthritic Disease and Implications for Obesity.
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ABSTRACT:
SUBMITTER: M??Donald IJ
PROVIDER: S-EPMC6471239 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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Associations between Adipokines in Arthritic Disease and Implications for Obesity.
MᵃᶜDonald Iona J IJ Liu Shan-Chi SC Huang Chien-Chung CC Kuo Shu-Jui SJ Tsai Chun-Hao CH Tang Chih-Hsin CH
International journal of molecular sciences 20190326 6
Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in inflammatory arthritis and obesity. This review considers the evidence generated over the last decade regarding the effects of several adipokines including leptin, adiponectin, visfatin, resistin, chemerin and apelin, in cartilage and bone homeostasis in the pathogenesis of rheumatoid arthritis and osteoarthritis, which ...[more]
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Project description:BackgroundObservational studies have indicated the association of alteration of adipokines with Alzheimer's disease (AD). However, it remains unclear whether the associations are causal.ObjectiveTo determine the causal associations between adipokines and AD.MethodsA Mendelian randomization (MR) method was applied to investigate the causal relationships of adipokines, including adiponectin and resistin, with risk of AD. Genetic proxies from genome-wide association studies (GWAS) of adiponectin and resistin were selected as instrumental variables. GWAS summary statistics for AD were extracted as outcome.ResultsIn this study, we found evidence of the causal effects of adiponectin on AD (OR: 0.850, 95% CI: 0.731-0.990, p = 0.037). However, no relationship between resistin and AD (OR: 0.936, 95% CI: 0.851-1.029, p = 0.171) was detected. In the reverse causation analysis, null associations of AD were found for adiponectin and resistin (all p > 0.05).ConclusionsThis study provides evidence of causality between adiponectin and risk of AD. However, no genetic susceptibility of resistin was discovered for AD.
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