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Associations between Adipokines in Arthritic Disease and Implications for Obesity.


ABSTRACT: Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in inflammatory arthritis and obesity. This review considers the evidence generated over the last decade regarding the effects of several adipokines including leptin, adiponectin, visfatin, resistin, chemerin and apelin, in cartilage and bone homeostasis in the pathogenesis of rheumatoid arthritis and osteoarthritis, which has important implications for obesity.

SUBMITTER: M??Donald IJ 

PROVIDER: S-EPMC6471239 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Associations between Adipokines in Arthritic Disease and Implications for Obesity.

MᵃᶜDonald Iona J IJ   Liu Shan-Chi SC   Huang Chien-Chung CC   Kuo Shu-Jui SJ   Tsai Chun-Hao CH   Tang Chih-Hsin CH  

International journal of molecular sciences 20190326 6


Secretion from adipose tissue of adipokines or adipocytokines, comprising of bioactive peptides or proteins, immune molecules and inflammatory mediators, exert critical roles in inflammatory arthritis and obesity. This review considers the evidence generated over the last decade regarding the effects of several adipokines including leptin, adiponectin, visfatin, resistin, chemerin and apelin, in cartilage and bone homeostasis in the pathogenesis of rheumatoid arthritis and osteoarthritis, which  ...[more]

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