Ontology highlight
ABSTRACT:
SUBMITTER: Almandil NB
PROVIDER: S-EPMC6471342 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190313 6
We have synthesized quinoxaline analogs (<b>1</b>⁻<b>25</b>), characterized by ¹H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC<sub>50</sub> = 38.68 ± 4.42 µM). The most potent compound among the series is analog <b>25</b> with IC<sub>50</sub> value 3.20 ± 0.10 µM. Sixteen analogs <b>1</b>, <b>2</b>, <b>3</b>, <b>4</b>, <b>5</b>, <b>6</b>, <b>7</b>, <b ...[more]