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Membrane-Freeze Concentration Hybrid for Temperature-Sensitive Biomolecules. Investigation, Application, and Techno-Economic Benefits.

ABSTRACT: In order to close the technology gap between membrane technologies and spray/freeze-drying ideally with a technology that avoids thermal stress to sensitive enzyme solutions, the limits of freeze concentration for this application have been investigated. On laboratory scale it was found that average crystal sizes are > 300 µm despite high viscosity and ice separation is possible up to 42 % solids and > 1000 mm²s^-1 viscosity. No activity loss was observed during concentration. A combination of two-stage freeze concentration with a filter and wash column for ice liquid separation in an integrated setup with ultrafiltration has the greatest potential and was shown to be economically feasible in three out of four cases studied.

SUBMITTER: van Beek T

PROVIDER: S-EPMC6472580 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Membrane-Freeze Concentration Hybrid for Temperature-Sensitive Biomolecules. Investigation, Application, and Techno-Economic Benefits.

van Beek Timo T Budde Michael M van Esch Jan J

Chemical engineering & technology 20181031 12

In order to close the technology gap between membrane technologies and spray/freeze-drying ideally with a technology that avoids thermal stress to sensitive enzyme solutions, the limits of freeze concentration for this application have been investigated. On laboratory scale it was found that average crystal sizes are > 300 µm despite high viscosity and ice separation is possible up to 42 % solids and > 1000 mm2s-1 viscosity. No activity loss was observed during concentratio ...[more]

PMID: 31007405

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