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Double-headed nanosystems for oral drug delivery.

ABSTRACT: We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces. The in vivo results suggest that the bioavailability of encapsulated curcumin is proportional to the ligand density rendered by double-headed nanosystems.

SUBMITTER: Kaur G 

PROVIDER: S-EPMC6472980 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Double-headed nanosystems for oral drug delivery.

Kaur G G   Kaur G G   Arora M M   Ganugula R R   Kumar M N V Ravi MNVR  

Chemical communications (Cambridge, England) 20190401 33

We demonstrate a novel strategy to engineer double-headed nanosystems by chemical modification of the carboxyl terminal polyester with a linker that offers tripodal arrangement of ligands on the particle surfaces. The in vivo results suggest that the bioavailability of encapsulated curcumin is proportional to the ligand density rendered by double-headed nanosystems. ...[more]

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