Ontology highlight
ABSTRACT:
SUBMITTER: Fox CB
PROVIDER: S-EPMC5435488 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Fox Cade B CB Cao Yuhong Y Nemeth Cameron L CL Chirra Hariharasudhan D HD Chevalier Rachel W RW Xu Alexander M AM Melosh Nicholas A NA Desai Tejal A TA
ACS nano 20160613 6
The oral route is preferred for systemic drug administration and provides direct access to diseased tissue of the gastrointestinal (GI) tract. However, many drugs have poor absorption upon oral administration due to damaging enzymatic and pH conditions, mucus and cellular permeation barriers, and limited time for drug dissolution. To overcome these limitations and enhance oral drug absorption, micron-scale devices with planar, asymmetric geometries, termed microdevices, have been designed to adh ...[more]