Ontology highlight
ABSTRACT:
SUBMITTER: Porte R
PROVIDER: S-EPMC6473065 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Porte Rémi R Davoudian Sadaf S Asgari Fatemeh F Parente Raffaella R Mantovani Alberto A Garlanda Cecilia C Bottazzi Barbara B
Frontiers in immunology 20190412
The first line of defense in innate immunity is provided by cellular and humoral mediators. Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate immunity. PTX3, the first long pentraxin identified, is a soluble pattern recognition molecule rapidly produced by several cell types in response to primary pro-inflammatory signals and microbial recognition. PTX3 acts as an important mediator of innate immunity against pathogens of fungal, bacterial and viral origin, a ...[more]