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Calcium-Dependent RTX Domains in the Development of Protein Hydrogels.

ABSTRACT: The RTX domains found in some pathogenic proteins encode repetitive peptide sequences that reversibly bind calcium and fold into the unique the ?-roll secondary structure. Several of these domains have been studied in isolation, yielding key insights into their structure/function relationships. These domains are increasingly being used in protein engineering applications, where the calcium-induced control over structure can be exploited to gain new functions. Here we review recent advances in the use of RTX domains in the creation of calcium responsive biomaterials.

SUBMITTER: Bulutoglu B

PROVIDER: S-EPMC6473919 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Calcium-Dependent RTX Domains in the Development of Protein Hydrogels.

Bulutoglu Beyza B Banta Scott S

Gels (Basel, Switzerland) 20190225 1

The RTX domains found in some pathogenic proteins encode repetitive peptide sequences that reversibly bind calcium and fold into the unique the β-roll secondary structure. Several of these domains have been studied in isolation, yielding key insights into their structure/function relationships. These domains are increasingly being used in protein engineering applications, where the calcium-induced control over structure can be exploited to gain new functions. Here we review recent advances in th ...[more]

PMID: 30823512

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