Ontology highlight
ABSTRACT:
SUBMITTER: Basu P
PROVIDER: S-EPMC6474384 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Basu Pallavi P Cai T Tony TT Das Kiranmoy K Sun Wenguang W
Journal of the American Statistical Association 20180612 523
The use of weights provides an effective strategy to incorporate prior domain knowledge in large-scale inference. This paper studies weighted multiple testing in a decision-theoretic framework. We develop oracle and data-driven procedures that aim to maximize the expected number of true positives subject to a constraint on the weighted false discovery rate. The asymptotic validity and optimality of the proposed methods are established. The results demonstrate that incorporating informative domai ...[more]