Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes.
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ABSTRACT:
SUBMITTER: Sharma DK
PROVIDER: S-EPMC6474412 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Sulfonamides Are an Overlooked Class of Electron Donors in Luminogenic Luciferins and Fluorescent Dyes.
Sharma Deepak K DK Adams Spencer T ST Liebmann Kate L KL Choi Adam A Miller Stephen C SC
Organic letters 20190305 6
Many fluorophores, and all bright light-emitting substrates for firefly luciferase, contain hydroxyl or amine electron donors. Sulfonamides were found to be capable of serving as replacements for these canonical groups. Unlike "caged" carboxamides, sulfonamide donors enable bioluminescence, and sulfonamidyl luciferins, coumarins, rhodols, and rhodamines are fluorescent in water. ...[more]
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