Ontology highlight
ABSTRACT:
SUBMITTER: Fernandes GW
PROVIDER: S-EPMC6474669 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Cell reports 20180101 2
Liver-specific disruption of the type 2 deiodinase gene (Alb-D2KO) results in resistance to both diet-induced obesity and liver steatosis in mice. Here, we report that this is explained by an ∼60% reduction in liver zinc-finger protein-125 (Zfp125) expression. Zfp125 is a Foxo1-inducible transcriptional repressor that causes lipid accumulation in the AML12 mouse hepatic cell line and liver steatosis in mice by reducing liver secretion of triglycerides and hepatocyte efflux of cholesterol. Zfp125 ...[more]