Ontology highlight
ABSTRACT:
SUBMITTER: Li JZ
PROVIDER: S-EPMC3484461 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Li John Zhong JZ Huang Yongcheng Y Karaman Ruchan R Ivanova Pavlina T PT Brown H Alex HA Roddy Thomas T Castro-Perez Jose J Cohen Jonathan C JC Hobbs Helen H HH
The Journal of clinical investigation 20121101 11
A genetic variant in PNPLA3 (PNPLA3(I148M)), a triacylglycerol (TAG) hydrolase, is a major risk factor for nonalcoholic fatty liver disease (NAFLD); however, the mechanism underlying this association is not known. To develop an animal model of PNPLA3-induced fatty liver disease, we generated transgenic mice that overexpress similar amounts of wild-type PNPLA3 (PNPLA3(WT)) or mutant PNPLA3 (PNPLA3(I148M)) either in liver or adipose tissue. Overexpression of the transgenes in adipose tissue did no ...[more]