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Dopamine receptor manipulation does not alter patterns of partner preference in long-term marmoset pairs.

ABSTRACT: The relationship between socially monogamous mates is dynamic and regulated by neurobiological influences. Research in rodent models has indicated a key role for the neurotransmitter dopamine (DA) and its receptors (DAR) in mediating the formation and maintenance of monogamous bonds. DAR activation was pharmacologically manipulated in marmosets housed in long-term pairs. Marmosets exposed to DAR manipulation were tested in a partner preference test under two social conditions: one in which their mate could visually observe their interactions with an opposite-sex individual, and one in which their pair mate could not visually observe these interactions. Marmosets displayed a spatial preference for the mate compared to an unfamiliar conspecific, however, they displayed a sexual preference for an unfamiliar conspecific over their mate. D1R manipulation had no impact on marmoset partner preference. However, activation of D2Rs reduced the time marmosets spent in contact with either stimulus animal, indicating a decrease in social interest, but did not reduce time spent in proximity to the stimulus animals nor number of sexual solicitations. Additionally, social context (visibility of the mate) did not influence marmoset behavior. These findings suggest that D2Rs may be involved in regulating generalized, but not partner-specific, social interest in marmoset monkeys.

SUBMITTER: Carp SB

PROVIDER: S-EPMC6475494 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Dopamine receptor manipulation does not alter patterns of partner preference in long-term marmoset pairs.

Carp Sarah B SB Taylor Jack H JH French Jeffrey A JA

Physiology & behavior 20190307

The relationship between socially monogamous mates is dynamic and regulated by neurobiological influences. Research in rodent models has indicated a key role for the neurotransmitter dopamine (DA) and its receptors (DAR) in mediating the formation and maintenance of monogamous bonds. DAR activation was pharmacologically manipulated in marmosets housed in long-term pairs. Marmosets exposed to DAR manipulation were tested in a partner preference test under two social conditions: one in which their ...[more]

PMID: 30853621

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Project description:Background: Extinction-based exposure therapy is used in treating anxiety- and trauma-related disorders, however there is the need to improve its limited efficacy in individuals with impaired fear extinction learning and to facilitate the inadequate protection against return-of-fear phenomena. Methods: Spontaneous recovery and fear renewal tests, assessed persistence and context-independence of treatments rescuing deficient fear extinction in 129S1/SvImJ mice. To reveal neurobiological mechanisms supporting long-lasting extinction rescue, whole-genome expression profiling, qRT-PCR, immunohistochemistry and chromatin immunoprecipitation were used. Results: Persistent and context-independent rescue of deficient fear extinction induced by dietary zinc-restriction was associated with enhanced expression of dopamine-related genes, such as genes encoding the dopamine- D1 (Drd1a) and -D2 (Drd2) receptor in the medial prefrontal cortex (mPFC) and amygdala. Moreover, enhanced histone acetylation was observed in the promoter of the extinction-regulated Drd2 gene in the mPFC, revealing a possibly involved gene regulatory mechanism. While enhancing histone acetylation, via administering the HDAC inhibitor MS275, does not induce successful fear reduction during extinction training, it promoted enduring and context-independent rescue of deficient fear extinction consolidation/retrieval once extinction learning was initiated. This was associated with enhanced neuronal histone acetylation in the mPFC and amygdala. Finally, as a proof of principle, mimicking enhanced dopaminergic signaling by L-dopa treatment rescued deficient fear extinction and co-administration of MS-275 rendered this effect enduring and context-independent. Conclusion: Current data reveal that combining dopaminergic and epigenetic mechanisms is a promising strategy to improve exposure-based behavior therapy in extinction-impaired individuals by initiating the formation of an enduring and context-independent fear inhibitory memory.

Dataset Information

Dopamine receptor manipulation does not alter patterns of partner preference in long-term marmoset pairs.

Publications

Dopamine receptor manipulation does not alter patterns of partner preference in long-term marmoset pairs.

Similar Datasets

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