Ontology highlight
ABSTRACT:
SUBMITTER: Kozlyuk N
PROVIDER: S-EPMC6475579 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Methods in molecular biology (Clifton, N.J.) 20190101
S100 proteins are distinct dimeric EF-hand Ca<sup>2+</sup>-binding proteins that can bind Zn<sup>2+</sup>, Mn<sup>2+</sup>, and other transition metals with high affinity at two sites in the dimer interface. Certain S100 proteins, including S100A7, S100A12, S100A8, and S100A9, play key roles in the innate immune response to pathogens. These proteins function via a "nutritional immunity" mechanism by depleting essential transition metals in the infection that are required for the invading organis ...[more]