Ontology highlight
ABSTRACT:
SUBMITTER: Vander Roest AS
PROVIDER: S-EPMC8214707 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Vander Roest Alison Schroer AS Liu Chao C Morck Makenna M MM Kooiker Kristina Bezold KB Jung Gwanghyun G Song Dan D Dawood Aminah A Jhingran Arnav A Pardon Gaspard G Ranjbarvaziri Sara S Fajardo Giovanni G Zhao Mingming M Campbell Kenneth S KS Pruitt Beth L BL Spudich James A JA Ruppel Kathleen M KM Bernstein Daniel D
Proceedings of the National Academy of Sciences of the United States of America 20210601 24
Hypertrophic cardiomyopathy (HCM) is the most common inherited form of heart disease, associated with over 1,000 mutations, many in β-cardiac myosin (MYH7). Molecular studies of myosin with different HCM mutations have revealed a diversity of effects on ATPase and load-sensitive rate of detachment from actin. It has been difficult to predict how such diverse molecular effects combine to influence forces at the cellular level and further influence cellular phenotypes. This study focused on the P7 ...[more]