Proteomics

Dataset Information

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Gut bacterial phytohormone modulates olfactory sensing, chemotaxis and mortality in fruit fly (Drosophila melanogaster): a new dimension to gut-brain axis

ABSTRACT: Aim of the study was to profile and quantify the proteins head region of D. melanogaster that are changing as a result of phytohormone administration. Data-independent acquisition (DIA) bases quantitative proteomics approach were used to achieve this aim. An Orbitrap Fusion Tribrid mass spectrometer (Thermo Fischer Scientific, Bremen, Germany) connected to the Easy- nLC-1200 nanoflow liquid chromatography system (Thermo Scientific) was used for data acquisition.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Drosophila Melanogaster (fruit Fly)

DISEASE(S): Disease Free

SUBMITTER: Keshava Prasad T. S.  

LAB HEAD: T. S. Keshava Prasad

PROVIDER: PXD044924 | Pride | 2024-05-22

REPOSITORIES: Pride

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Dataset's files

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Action DRS
Drosophila_DDA_spec_lib_Fr1.raw Raw
Drosophila_DDA_spec_lib_Fr2.raw Raw
Drosophila_DDA_spec_lib_Fr3.raw Raw
Drosophila_DDA_spec_lib_Fr4.raw Raw
Drosophila_DDA_spec_lib_Fr5.raw Raw
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Publications

Comprehensive insights into the impact of bacterial indole-3-acetic acid on sensory preferences in Drosophila melanogaster.

Aziz Raifa Abdul RA   Ramesh Poornima P   Suchithra Kokkarambath Vannadil KV   Stothard Paul P   Narayana Vanya Kadla VK   Raghu Shamprasad Varija SV   Shen Fo-Ting FT   Young Chiu-Chung CC   Prasad T S Keshava TSK   Hameed Asif A  

Scientific reports 20240409 1

Several bacteria of environmental and clinical origins, including some human-associated strains secrete a cross-kingdom signaling molecule indole-3-acetic acid (IAA). IAA is a tryptophan (trp) derivative mainly known for regulating plant growth and development as a hormone. However, the nutritional sources that boost IAA secretion in bacteria and the impact of secreted IAA on non-plant eukaryotic hosts remained less explored. Here, we demonstrate significant trp-dependent IAA production in Pseud  ...[more]

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