Ontology highlight
ABSTRACT:
SUBMITTER: Sharifi M
PROVIDER: S-EPMC6477004 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sharifi Mahtab M Futema Marta M Nair Devaki D Humphries Steve E SE
Current cardiology reports 20190422 6
<h4>Purpose of the review</h4>Identification of loci and common single-nucleotide polymorphisms (SNPs) that have modest effects on plasma lipids have been used to confirm or refute the causal role of lipid traits in the development of coronary heart disease (CHD), and as tools to identify individuals with polygenic hypercholesterolemia.<h4>Recent findings</h4>Several groups have reported on the use of SNP scores in distinguishing individuals with a clinical diagnosis of familial hypercholesterol ...[more]