Ontology highlight
ABSTRACT:
SUBMITTER: Scarfo I
PROVIDER: S-EPMC6477509 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Scarfò Irene I Frigault Matthew J MJ Maus Marcela V MV
Frontiers in oncology 20190416
Cutaneous T cell lymphomas (CTCL) are a heterogeneous group of malignancies characterized by the expansion of a malignant T cell clone. Chimeric Antigen Receptor (CAR) T cell therapy has shown impressive results for the treatment of B-cell tumors, but several challenges have prevented this approach in the context of T cell lymphoma. These challenges include the possibilities of fratricide due to shared T-cell antigens, T cell immunodeficiency, and CAR transduction of malignant cells if CAR T are ...[more]