Remote ischaemic preconditioning in isolated aortic valve and coronary artery bypass surgery: a randomized trial†.

ABSTRACT:

Objectives

This trial was designed and patients were recruited at a time when the benefits of remote ischaemic preconditioning during open-heart surgery were still controversial. We focused on a homogeneous patient population undergoing either isolated aortic valve replacement or coronary artery bypass grafting (CABG) surgery by investigating cardiac injury, metabolic stress and inflammatory response.

Methods

A 2-centre randomized controlled trial recruited a total of 124 patients between February 2013 and April 2015. Of them, 64 patients underwent CABG and 60 patients underwent aortic valve replacement. Patients were randomized to either sham or preconditioning. Remote ischaemic preconditioning was applied following anaesthesia and before sternotomy. Myocardial injury and i

SUBMITTER: Moscarelli M 

PROVIDER: S-EPMC6477640 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature