Ontology highlight
ABSTRACT:
SUBMITTER: Linsley PS
PROVIDER: S-EPMC6477779 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Linsley Peter S PS Greenbaum Carla J CJ Rosasco Mario M Presnell Scott S Herold Kevan C KC Dufort Matthew J MJ
Genes and immunity 20180621 4
Biologic treatment of type 1 diabetes (T1D) with agents including anti-CD3 (otelixizumab and teplizumab), anti-CD20 (rituximab), LFA3Ig (alafacept), and CTLA4Ig (abatacept) results in transient stabilization of insulin C-peptide, a surrogate for endogenous insulin secretion. With the goal of inducing more robust immune tolerance, we used systems biology approaches to elucidate mechanisms associated with C-peptide stabilization in clinical trial blood samples from new-onset T1D subjects treated w ...[more]