Ontology highlight
ABSTRACT:
SUBMITTER: Thounaojam MC
PROVIDER: S-EPMC6477903 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Thounaojam Menaka C MC Montemari Annalisa A Powell Folami L FL Malla Prerana P Gutsaeva Diana R DR Bachettoni Alessandra A Ripandelli Guido G Repossi Andrea A Tawfik Amany A Martin Pamela M PM Facchiano Francesco F Bartoli Manuela M
Diabetes 20190206 5
We have investigated the contributing role of monosodium urate (MSU) to the pathological processes associated with the induction of diabetic retinopathy (DR). In human postmortem retinas and vitreous from donors with DR, we have found a significant increase in MSU levels that correlated with the presence of inflammatory markers and enhanced expression of xanthine oxidase. The same elevation in MSU levels was also detected in serum and vitreous of streptozotocin-induced diabetic rats (STZ-rats) a ...[more]