Ontology highlight
ABSTRACT:
SUBMITTER: Hirata Y
PROVIDER: S-EPMC6478420 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Hirata Yu Y Nomura Kazuhiro K Senga Yoko Y Okada Yuko Y Kobayashi Kenta K Okamoto Shiki S Minokoshi Yasuhiko Y Imamura Michihiro M Takeda Shin'ichi S Hosooka Tetsuya T Ogawa Wataru W
JCI insight 20190221 4
Diabetes mellitus is associated with various disorders of the locomotor system including the decline in mass and function of skeletal muscle. The mechanism underlying this association has remained ambiguous, however. We now show that the abundance of the transcription factor KLF15 as well as the expression of genes related to muscle atrophy are increased in skeletal muscle of diabetic model mice, and that mice with muscle-specific KLF15 deficiency are protected from the diabetes-induced decline ...[more]