Ontology highlight
ABSTRACT:
SUBMITTER: Cho S
PROVIDER: S-EPMC6479247 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cho Soonweng S Kim Hyun-Seok HS Zeiger Martha A MA Umbricht Christopher B CB Cope Leslie M LM
Journal of computational biology : a journal of computational molecular cell biology 20190221 4
Genetic and epigenetic changes drive carcinogenesis, and their integrated analysis provides insights into mechanisms of cancer development. Computational methods have been developed to measure copy number variation (CNV) from methylation array data, including ChAMP-CNV, CN450K, and, introduced here, Epicopy. Using paired single nucleotide polymorphism (SNP) and methylation array data from the public The Cancer Genome Atlas repository, we optimized CNV calling and benchmarked the performance of t ...[more]