Ontology highlight
ABSTRACT:
SUBMITTER: Bignell GR
PROVIDER: S-EPMC327104 | biostudies-literature | 2004 Feb
REPOSITORIES: biostudies-literature
Bignell Graham R GR Huang Jing J Greshock Joel J Watt Stephen S Butler Adam A West Sofie S Grigorova Mira M Jones Keith W KW Wei Wen W Stratton Michael R MR Futreal P Andrew PA Weber Barbara B Shapero Michael H MH Wooster Richard R
Genome research 20040201 2
Genomic copy number alterations are a feature of many human diseases including cancer. We have evaluated the effectiveness of an oligonucleotide array, originally designed to detect single-nucleotide polymorphisms, to assess DNA copy number. We first showed that fluorescent signal from the oligonucleotide array varies in proportion to both decreases and increases in copy number. Subsequently we applied the system to a series of 20 cancer cell lines. All of the putative homozygous deletions (10) ...[more]