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The Roles of MicroRNA in Lung Cancer.


ABSTRACT: Lung cancer is the most devastating malignancy in the world. Beyond genetic research, epigenomic studies-especially investigations of microRNAs-have grown rapidly in quantity and quality in the past decade. This has enriched our understanding about basic cancer biology and lit up the opportunities for potential therapeutic development. In this review, we summarize the involvement of microRNAs in lung cancer carcinogenesis and behavior, by illustrating the relationship to each cancer hallmark capability, and in addition, we briefly describe the clinical applications of microRNAs in lung cancer diagnosis and prognosis. Finally, we discuss the potential therapeutic use of microRNAs in lung cancer.

SUBMITTER: Wu KL 

PROVIDER: S-EPMC6480472 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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The Roles of MicroRNA in Lung Cancer.

Wu Kuan-Li KL   Tsai Ying-Ming YM   Lien Chi-Tun CT   Kuo Po-Lin PL   Hung And Jen-Yu AJ  

International journal of molecular sciences 20190331 7


Lung cancer is the most devastating malignancy in the world. Beyond genetic research, epigenomic studies-especially investigations of microRNAs-have grown rapidly in quantity and quality in the past decade. This has enriched our understanding about basic cancer biology and lit up the opportunities for potential therapeutic development. In this review, we summarize the involvement of microRNAs in lung cancer carcinogenesis and behavior, by illustrating the relationship to each cancer hallmark cap  ...[more]

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