Ontology highlight
ABSTRACT:
SUBMITTER: Pernice HF
PROVIDER: S-EPMC6480955 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Pernice Helena F HF Schieweck Rico R Jafari Mehrnoosh M Straub Tobias T Bilban Martin M Kiebler Michael A MA Popper Bastian B
International journal of molecular sciences 20190411 7
Staufen2 (Stau2) is an RNA-binding protein that is involved in dendritic spine morphogenesis and function. Several studies have recently investigated the role of Stau2 in the regulation of its neuronal target mRNAs, with particular focus on the hippocampus. Here, we provide evidence for Stau2 expression and function in cerebellar Purkinje cells. We show that Stau2 downregulation (Stau2<sup>GT</sup>) led to an increase of glutamate receptor ionotropic delta subunit 2 (GluD2) in Purkinje cells whe ...[more]