Ontology highlight
ABSTRACT:
SUBMITTER: Ni X
PROVIDER: S-EPMC6481611 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ni Xuhao X Tao Jinhui J Barbi Joseph J Chen Qian Q Park Benjamin V BV Li Zhiguang Z Zhang Nailing N Lebid Andriana A Ramaswamy Anjali A Wei Ping P Zheng Ying Y Zhang Xuehong X Wu Xingmei X Vignali Paolo P Yang Cui-Ping CP Li Huabin H Pardoll Drew D Lu Ling L Pan Duojia D Pan Fan F
Cancer discovery 20180615 8
Regulatory T cells (Treg) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective antitumor immune responses. FOXP3 is a transcription factor expressed in Tregs that is required for their function. However, the pathways and microenvironmental cues governing FOXP3 expression and Treg function are not completely understood. Herein, we report that YAP, a coactivator of the Hippo pathway, is highly expressed in Tregs and bolsters FOXP3 ...[more]