Ontology highlight
ABSTRACT:
SUBMITTER: Papp E
PROVIDER: S-EPMC6481945 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Papp Eniko E Hallberg Dorothy D Konecny Gottfried E GE Bruhm Daniel C DC Adleff Vilmos V Noë Michaël M Kagiampakis Ioannis I Palsgrove Doreen D Conklin Dylan D Kinose Yasuto Y White James R JR Press Michael F MF Drapkin Ronny R Easwaran Hariharan H Baylin Stephen B SB Slamon Dennis D Velculescu Victor E VE Scharpf Robert B RB
Cell reports 20181101 9
To improve our understanding of ovarian cancer, we performed genome-wide analyses of 45 ovarian cancer cell lines. Given the challenges of genomic analyses of tumors without matched normal samples, we developed approaches for detection of somatic sequence and structural changes and integrated these with epigenetic and expression alterations. Alterations not previously implicated in ovarian cancer included amplification or overexpression of ASXL1 and H3F3B, deletion or underexpression of CDC73 an ...[more]