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Enantioselective Palladium-Catalyzed Oxidative ?,?-Fluoroarylation of ?,?-Unsaturated Carbonyl Derivatives.

ABSTRACT: The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective ?-fluorination of ?,?-unsaturated systems.

SUBMITTER: Miro J

PROVIDER: S-EPMC6482284 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Enantioselective Palladium-Catalyzed Oxidative β,β-Fluoroarylation of α,β-Unsaturated Carbonyl Derivatives.

Miró Javier J Del Pozo Carlos C Toste F Dean FD Fustero Santos S

Angewandte Chemie (International ed. in English) 20160607 31

The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective β-fluorination of α,β-unsaturated systems. ...[more]

PMID: 27272390

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